Compiled by the ENCLAI research team following a documented methodology · Editorial oversight: Dr Natalya Mathur, Founder · Data last updated: (UTC)

Mpox (monkeypox) in Puerto Rico: 2026 cases and outbreak reports

Reported mpox (monkeypox) surveillance for Puerto Rico (PRI) — — latest record 2026-10-25

What the 2026 data shows

As of 25 October 2026, Puerto Rico has reported 3 mpox (monkeypox) cases in 2026, compiled from figures published by CDC NNDSS Weekly Notifiable Diseases (State-Level). The full year 2025 closed at 10 cases.

Of the 40 countries reporting mpox (monkeypox) to ENCLAI in 2026, Puerto Rico accounts for 0.0% of reported cases and ranks 36 by case count.

ENCLAI has logged 39 surveillance records for mpox (monkeypox) in Puerto Rico in 2026, with the most detailed reporting in Mar 2026 (5 records). 3 of those arrived in the last 30 days; the case counts run to 2026-10-25. 1 distinct surveillance sources reported this pair in 2026.

Reporting authorities for these counts: CDC NNDSS Weekly Notifiable Diseases (State-Level)

Key facts: Mpox (monkeypox)

Transmission
Close contact
Skin-to-skin (including sex), mouth-to-mouth or mouth-to-skin; contaminated linen; mother to child; animal bites or handling.WHO 2024
Incubation
≈ 1 week
Range 1–21 days after exposure.WHO 2024
Vaccine
Yes — high-risk groups
Pre-exposure for health workers, household contacts, people with multiple partners and sex workers; post-exposure within 4 days of contact, up to 14 if symptom-free.WHO 2024

Cited reference facts about the disease, not derived from the surveillance counts on this page. Full set on the Mpox (monkeypox) page.

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Surveillance summary

2026 cases (YTD)
3
2025 cases (full year)
10
Baseline avg (3yr)
N/A
Trend (2025)
—
No comparable earlier years

Reported cases by year, Puerto Rico

YearReported casesShare of worldwide reports
2023 not reported —
2024 not reported —
2025 10 0.2%
2026 (year to date) 3 0.0%

Reporting bounds and case definitions vary; historical baselines are a separate comparison measure. Worldwide share compares this country's reported figure with the sum of all countries reporting mpox (monkeypox) to ENCLAI for that year. "Incomplete year" means our sources cover less than ten months of that year, so no full-year figure is shown; "outbreak total to date" is a running total since an outbreak began, not a count for one year.

Surveillance records logged in 2026

MonthRecordsReporting sources
Jan 202611
Feb 202631
Mar 202651
Apr 202641
May 202651
Jun 202641
Jul 202641
Aug 202651
Sep 202641
Oct 202641

A record is one dated surveillance publication or one row of an official table; a month with many records is a month with detailed reporting, not necessarily more cases. 3 records were logged in the last 30 days.

Sub-national reporting, 2026

Areas within Puerto Rico with the most mpox (monkeypox) records this year:

AreaRecords
Puerto Rico39

Mpox (monkeypox) in other countries, 2026

Country2026 casesTrend
DR Congo 25,392
Uganda 8,498 (outbreak total to date)
Sierra Leone 5,442 (outbreak total to date)
Burundi 4,727
Madagascar 3,534 (outbreak total to date)

Other diseases reported in Puerto Rico, 2026

Disease2026 casesTrend
Chlamydia infection 2,012
Hepatitis C 1,335
Dengue fever 940
Gonococcal infection 442
Non-typhoidal salmonellosis 331

Questions about this page

How many mpox (monkeypox) cases has Puerto Rico reported in 2026?
As of 25 October 2026, Puerto Rico has reported 3 mpox (monkeypox) cases in 2026, compiled from figures published by CDC NNDSS Weekly Notifiable Diseases (State-Level). The full year 2025 closed at 10 cases.
Where does Puerto Rico publish mpox (monkeypox) surveillance data?
The counts on this page were published by CDC NNDSS Weekly Notifiable Diseases (State-Level). ENCLAI compiles and normalises them and is not affiliated with these authorities.

About this data

Figures are reported case counts as published by the originating health authorities, compiled by ENCLAI from 444 verified surveillance sources. Puerto Rico figures reflect the reporting available to ENCLAI; reporting periods and case definitions differ between sources, and a missing report does not establish zero cases. ENCLAI holds mpox (monkeypox) records for Puerto Rico dated from 2025. How we verify and update data: methodology & Trust Center · understanding case counts.

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The daily disease brief

One email a day: what changed in official disease reporting worldwide, with the source named for every number. Reported facts only — no forecasts and no interpretation.

Double opt-in — we send a confirmation link and nothing else until you click it. One-click unsubscribe on every email. See our privacy notice.